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ETAS Logo

Award-Winning Ingredient for Stress, Mood, and Cognitive Health

ETAS is a proprietary asparagus extract powder clinically proven to reduce biological stress response, improve sleep quality and support cognitive function.

STATUS
Dairy-free Icon
DSHEA Icon
Halal Icon
Kosher Icon
Self-affirmed Gras Icon
Non-GMO Icon
FUNCTIONS
Brain Health Icon
Skin Support Icon
Sleep Icon
Stress Support Icon

WINNER: BRAIN HEALTH

SupplySide West’s 2022 Ingredient Idol for Brain Health

INGREDIENT IDOL 2022

ETAS is the winner of SupplySide West’s 2022 Ingredient Idol for Brain Health. Recognized for its impact on stress, mood, sleep and cognitive health, ETAS is also upcycled from the white portion of asparagus stalks that would otherwise go to waste, providing manufacturers environmental sustainability claims.

Scroll down to find out more about formulating with ETAS.

Asparagus Bundle

Finding the right organic asparagus extract powder ingredients to buy — especially if you’re searching for asparagus extract powder ingredients online — is not always easy, but with ETAS enzyme treated asparagus it is.

ETAS is a proprietary ingredient derived from the tough lower portion of asparagus stalks, which has the unique ability to increase the production of heat shock protein 70 (HSP70).* Regarding asparagus extract powder health benefits, double-blind, placebo-controlled research has shown ETAS effectively:

Increases quality of sleep*[1]

Alleviates occasional stress by improving heart rate variability*[2]

Raises cognitive performance, reduces fatigue, and improves the stress response*[3],[4],[5]

The extraction process used to create ETAS asparagus extract powder results in unique hydroxymethyl furfural derivatives — particularly asfural — that are not contained in raw asparagus extract.

MECHANISM OF ACTION

Asparagus Extract Powder Benefits

ETAS asparagus extract powder works by increasing the production of HSP70 — an intracellular protein produced naturally by the body when it encounters a stressor, such as extreme heat.*[6]

HSP70 has many beneficial functions. It repairs damaged cells, tips the balance from excitatory cytokines to inhibitory ones and serves as an antioxidant.*[7],[8],[9] Unfortunately, the heat shock response to stressors of all kinds decreases with age.[10],[11] Human clinical research has shown that ETAS significantly increases the expression of HSP70 at a dosage of 100 mg elemental ETAS asparagus extract powder per day.*[12] (The commercially available form of ETAS powder is 50% elemental ETAS, requiring a dosage of 200 mg per day.)

Sleeping Aged Woman
HSP Induction - ETAS

Innovative Asparagus Extract Which Induces HSP

The first and only HSP-inducing dietary ingredient in the world. Several active components are identified in ETAS for the HSP-inducing effect.

Asparagus Stalk

What is HSP? (Heat Shock Protein)

• All proteins need to be folded to work correctly

• HSP helps such protein folding as “chaperone” by stabilizing new proteins to ensure correct folding, or by helping to refold proteins that were damaged by the cell stress.

• HSP is found in virtually all living organisms, from bacteria to humans.

Stresses

Unfolded Protein

Unfolded Protein

Dysfunctional
Misfunctional

HSP repairs…

HSP Repairs
Not Repairable Protein

HSP repairs…

If not repairable…

Refolded
normal protein

Refolded Normal Protein

Decomposed
protein

Asparagus Stalk

Three Tangible Effects

HSP
INDUCTION

White smiley image

Stress
Relief

White moon and starts image

Better
Sleep

White outline brain Image

Brain
Function

White smiley image

Stress Relief

HSP Modulates Stress Levels

Function of cortisol in stress

Short term and more prolonged stress image

Stress

Green down arrow

Cortisol

Green down arrow

Cortisol receptor forms complex with HSP and detects cortisol

Right green border with Arrow

Negative feedback

J Biol Chem. 1994 Feb 18;269(7):5043-9.
Cortisol Saliva Chromogranin A
CORT line graph
Saliva IgA Autonomic Nerve Balance

AN Balance

Bar graph An Balance

AN Activity

Bar graph An Activity

Physical Stress

Bar graph physical stress

Mental Stress

Bar graph mental stress
Journal of Nutritional Science and Vitaminology, 60(4): 223-304 (2014)
White moon and starts image

Better Sleep

HSP Modulates Sleep Rhythm

(Resets Circadian Rhythm)
Science, 330(6002), 379-385 (2010)

Sleep Time Wave Graph
Sleep Time Bar Graph ETAS vs Placebo

Journal of Nutritional Science and Vitaminology,
60(4): 283-290 (2014)

Place vs ETAS Effect at night
In the group with poor sleep efficiency, ETAS enabled longer sleep.
Placebo vs ETAS effect in the morning
In the group with poor sleep efficiency, ETAS enabled longer sleep.
Cloud Transparent
White outline brain Image

Brain
Function

HSP Modulates Sleep Rhythm

HSP Amyloid SNP CoCl2 Image

HSP Repairs Misfolded Proteins and Removes Debris

Unfolded Protein
HSP Repairs
Not Repairable Protein
Refolded Normal Protein
ETAS Flow1 Image

Supports Neuron Cell Growth

Right Green Arrow
ETAS Flow3 Image
Better Neural
Network Formation
ETAS Calculation Image
Placebo ETAS Bar Graph
# of correct answers

POMS (Profile of Mood States)

Placebo Graph
ETAS Graph

A New Study:
Ageing (senescence)-accelerated mice

  • Improved behavior and memory
  • HSP70 increased in brain
  • Amyloid-β decreased in brain
  • Neuron cells increased in brain
MDPI Nutrients Logo

Article

A Standardized Extract of Asparagus officinalis Stem (ETAS®) Ameliorates Cognitive Impairment, Inhibits Amyloid β Deposition via BACE-1 and Normalizes Circadian Rhythm Signaling via MT1 and MT2

MDPI Nutrients Source
Depositions Bar Graph
Number of Neurons Bar Graph

Cell

Circle-wave image

STRESS

Heat, infection, inflammation, reactive oxygen species, UV, etc.

Right Arrow Image
HSP Expression Image
HSP expression increase
Function as
housekeeping
"Chaperone"

What is "Chaperone"?

Unfolded Ptotein Image

Unfolded protein
(dysfunctional / misfunctional)

Chaperone

HSP Chaperone Arrow Image
HSP
Left Bracket Image
Refolded Functional Protein Image

Refolded
functional protein

OR
Decomposed Protein Image

Decomposed protein
(if irreparable)

HSP expression and ETAS function mechanism

ETAS Stimulation

Flow Chart ETAS Stimulaiton
  1. HSP70 is stable as a complex with HSF1*1.
  2. When needed, HSP70 is released from the complex and activated.
    ⟶ to repair unfolded proteins.
  3. HSF-1 is phosphorylated and forms trimer.
  4. HSF-1 trimer moves into nucleus and binds to HSE*2 on DNA.
  5. Transcription and exportation of HSP70 mRNA
  6. HSP70 is translated to HSP70 protein.

  • *1 HSF-1: Heat shock factor-1
    Transcription factor which controls HP expression
  • *2 HSE: Heat shock element Gene sequences in promoter region

Reference: Cell Stress Chaperones. 2012 Jan:17/1):1-9.

The safety of ETAS is assured by in vitro, animal and clinical studies.
Regulatory Toxicology and pharmacology: submitted

Active Components

Several active components are identified in ETAS for HSP-induction, and ETAS is standardized with the component group “Asparaprolines” asparagus-derived proline-containing 3-alkyldiketopiperazines”.

Cyclo Atoms
Bracket down image

Asparaprolines; a standard component group of ETAS

SAFETY

ETAS is a natural ingredient derived from asparagus, which has been safely consumed as part of the food chain for at least 5,000 years. A 90-day toxicological study found no significant adverse events and confirmed the ingredient’s safety. [13]

ETAS Logo
*These statements have not been evaluated by the Food & Drug Administration. This product is not intended to diagnose, treat, cure or prevent any disease.

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