Award-Winning Ingredient for Stress, Mood, and Cognitive Health
ETAS is a proprietary asparagus extract powder derived from Asparagus officinals clinically proven to reduce biological stress response, improve sleep quality, and support cognitive function
STATUS
FUNCTIONS
ETAS: WINNER IN BRAIN HEALTH
INGREDIENT IDOL 2022
Proprietary ETAS asparagus extract powder is the winner of SupplySide West’s 2022 Ingredient Idol for Brain Health. Recognized for its impact on stress, mood, sleep and cognitive health, ETAS asparagus stalk powder is also upcycled from the white portion of asparagus stalks that would otherwise go to waste, providing manufacturers environmental sustainability claims.
For those manufacturers who are seeking asparagus extract powder online, scroll down to find out more about formulating with the proprietary ETAS asparagus stalk ingredient.
Finding the right organic asparagus extract powder ingredients to buy — especially if you’re searching for asparagus extract powder ingredients online — is not always easy, but with ETAS enzyme treated asparagus it is.
ETAS is a proprietary ingredient derived from the tough lower portion of asparagus stalks, which has the unique ability to increase the production of heat shock protein 70 (HSP70).* Regarding asparagus extract powder health benefits, double-blind, placebo-controlled research has shown ETAS effectively:
- • Increases quality of sleep*[1]
- • Alleviates occasional stress by improving heart rate variability*[2]
- • Raises cognitive performance, reduces fatigue, and improves the stress response*[3],[4],[5]
The extraction process used to create ETAS asparagus extract powder results in unique hydroxymethyl furfural derivatives — particularly asfural — that are not contained in raw asparagus extract.
MECHANISM OF ACTION
Asparagus Extract Powder Benefits
ETAS asparagus extract powder works by increasing the production of HSP70 — an intracellular protein produced naturally by the body when it encounters a stressor, such as extreme heat.*[6]
HSP70 has many beneficial functions. It repairs damaged cells, tips the balance from excitatory cytokines to inhibitory ones and serves as an antioxidant.*[7],[8],,[9] Unfortunately, the heat shock response to stressors of all kinds decreases with age.[10],[11] Human clinical research has shown that ETAS significantly increases the expression of HSP70 at a dosage of 100 mg elemental ETAS asparagus extract powder per day.*[12] (The commercially available form of ETAS powder is 50% elemental ETAS, requiring a dosage of 200 mg per day.)
Innovative Asparagus Extract Which Induces HSP
The first and only HSP-inducing dietary ingredient in the world. Several active components are identified in ETAS for the HSP-inducing effect.
What is HSP? (Heat Shock Protein)
• All proteins need to be folded to work correctly
• HSP helps such protein folding as “chaperone” by stabilizing new proteins to ensure correct folding, or by helping to refold proteins that were damaged by the cell stress.
• HSP is found in virtually all living organisms, from bacteria to humans.
Unfolded Protein
Dysfunctional
Misfunctional
HSP repairs…
HSP repairs…
If not repairable…
Refolded
normal protein
Decomposed
protein
Three Tangible Effects
HSP
INDUCTION
Asparagus extract powder benefits include three tangible effects:
Stress
Relief
Better
Sleep
Brain
Function
Stress Relief
HSP Modulates Stress Levels
Function of cortisol in stress
Stress
Cortisol
Cortisol receptor forms complex with HSP and detects cortisol
Negative feedback
J Biol Chem. 1994 Feb 18;269(7):5043-9.
AN Balance
AN Activity
Physical Stress
Mental Stress
Better Sleep
Heat Shock Protein 70 (HSP70) Modulates Sleep Rhythm
(Resets Circadian Rhythm)
Science, 330(6002), 379-385 (2010)
Journal of Nutritional Science and Vitaminology,
60(4): 283-290 (2014)
In the group with poor sleep efficiency, ETAS enabled longer sleep.
In the group with poor sleep efficiency, ETAS enabled longer sleep.
Brain
Function
HSP Protects Neurons from Stressors
HSP Repairs Misfolded Proteins and Removes Debris
Supports Neuron Cell Growth
Network Formation
POMS (Profile of Mood States)
A New Study:
Ageing (senescence)-accelerated mice
- Improved behavior and memory
- HSP70 increased in brain
- Amyloid-β decreased in brain
- Neuron cells increased in brain
Article
A Standardized Extract of Asparagus officinalis Stem (ETAS®) Ameliorates Cognitive Impairment, Inhibits Amyloid β Deposition via BACE-1 and Normalizes Circadian Rhythm Signaling via MT1 and MT2
Cell
STRESS
Heat, infection, inflammation, reactive oxygen species, UV, etc.
housekeeping
"Chaperone"
What is "Chaperone"?
Unfolded protein
(dysfunctional / misfunctional)
Chaperone
Refolded
functional protein
Decomposed protein
(if irreparable)
HSP expression and ETAS function mechanism
ETAS Stimulation
- HSP70 is stable as a complex with HSF1*1.
- When needed, HSP70 is released from the complex and activated.
⟶ to repair unfolded proteins. - HSF-1 is phosphorylated and forms trimer.
- HSF-1 trimer moves into nucleus and binds to HSE*2 on DNA.
- Transcription and exportation of HSP70 mRNA
- HSP70 is translated to HSP70 protein.
- *1 HSF-1: Heat shock factor-1
Transcription factor which controls HP expression - *2 HSE: Heat shock element Gene sequences in promoter region
Reference: Cell Stress Chaperones. 2012 Jan:17/1):1-9.
The safety of ETAS is assured by in vitro, animal and clinical studies.
Regulatory Toxicology and pharmacology: submitted
Active Components
Several active components are identified in ETAS for Heat Shock Protein 70 (HSP70) induction, and ETAS is standardized with the component group “Asparaprolines” asparagus-derived proline-containing 3-alkyldiketopiperazines”.
Asparaprolines; a standard component group of ETAS
SAFETY
ETAS is a natural ingredient derived from asparagus, which has been safely consumed as part of the food chain for at least 5,000 years. A 90-day toxicological study found no significant adverse events and confirmed the ingredient’s safety. [13]
For manufacturers seeking asparagus extract powder for sale, and those who are looking for asparagus extract powder bulk options, please contact your Maypro representative.
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