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Award-Winning Ingredient for Stress, Mood, and Cognitive Health

ETAS is a proprietary asparagus extract powder derived from Asparagus officinals clinically proven to reduce biological stress response, improve sleep quality, and support cognitive function

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SupplySide West’s 2022 Ingredient Idol for Brain Health


Proprietary ETAS asparagus extract powder is the winner of SupplySide West’s 2022 Ingredient Idol for Brain Health. Recognized for its impact on stress, mood, sleep and cognitive health, ETAS asparagus stalk powder is also upcycled from the white portion of asparagus stalks that would otherwise go to waste, providing manufacturers environmental sustainability claims.

For those manufacturers who are seeking asparagus extract powder online, scroll down to find out more about formulating with the proprietary ETAS asparagus stalk ingredient.

Asparagus Bundle

Finding the right organic asparagus extract powder ingredients to buy — especially if you’re searching for asparagus extract powder ingredients online — is not always easy, but with ETAS enzyme treated asparagus it is.

ETAS is a proprietary ingredient derived from the tough lower portion of asparagus stalks, which has the unique ability to increase the production of heat shock protein 70 (HSP70).* Regarding asparagus extract powder health benefits, double-blind, placebo-controlled research has shown ETAS effectively:

  • • Increases quality of sleep*[1]
  • • Alleviates occasional stress by improving heart rate variability*[2]
  • • Raises cognitive performance, reduces fatigue, and improves the stress response*[3],[4],[5]

The extraction process used to create ETAS asparagus extract powder results in unique hydroxymethyl furfural derivatives — particularly asfural — that are not contained in raw asparagus extract.


Asparagus Extract Powder Benefits

ETAS asparagus extract powder works by increasing the production of HSP70 — an intracellular protein produced naturally by the body when it encounters a stressor, such as extreme heat.*[6]

HSP70 has many beneficial functions. It repairs damaged cells, tips the balance from excitatory cytokines to inhibitory ones and serves as an antioxidant.*[7],[8],,[9] Unfortunately, the heat shock response to stressors of all kinds decreases with age.[10],[11] Human clinical research has shown that ETAS significantly increases the expression of HSP70 at a dosage of 100 mg elemental ETAS asparagus extract powder per day.*[12] (The commercially available form of ETAS powder is 50% elemental ETAS, requiring a dosage of 200 mg per day.)

Sleeping Aged Woman

Innovative Asparagus Extract Which Induces HSP

The first and only HSP-inducing dietary ingredient in the world. Several active components are identified in ETAS for the HSP-inducing effect.

Asparagus Stalk

What is HSP? (Heat Shock Protein)

• All proteins need to be folded to work correctly

• HSP helps such protein folding as “chaperone” by stabilizing new proteins to ensure correct folding, or by helping to refold proteins that were damaged by the cell stress.

• HSP is found in virtually all living organisms, from bacteria to humans.


Unfolded Protein

Unfolded Protein


HSP repairs…

HSP Repairs
Not Repairable Protein

HSP repairs…

If not repairable…

normal protein

Refolded Normal Protein


Asparagus Stalk

Three Tangible Effects


Asparagus extract powder benefits include three tangible effects:

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Stress Relief

HSP Modulates Stress Levels

Function of cortisol in stress

Short term and more prolonged stress image


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Green down arrow

Cortisol receptor forms complex with HSP and detects cortisol

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Negative feedback

J Biol Chem. 1994 Feb 18;269(7):5043-9.
Cortisol Saliva Chromogranin A
CORT line graph
Saliva IgA Autonomic Nerve Balance

AN Balance

Bar graph An Balance

AN Activity

Bar graph An Activity

Physical Stress

Bar graph physical stress

Mental Stress

Bar graph mental stress
Journal of Nutritional Science and Vitaminology, 60(4): 223-304 (2014)
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Better Sleep

Heat Shock Protein 70 (HSP70)
Modulates Sleep Rhythm

(Resets Circadian Rhythm)
Science, 330(6002), 379-385 (2010)

Sleep Time Wave Graph
Sleep Time Bar Graph ETAS vs Placebo

Journal of Nutritional Science and Vitaminology,
60(4): 283-290 (2014)

Place vs ETAS Effect at night
In the group with poor sleep efficiency, ETAS enabled longer sleep.
Placebo vs ETAS effect in the morning
In the group with poor sleep efficiency, ETAS enabled longer sleep.
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HSP Protects Neurons from Stressors

HSP Amyloid SNP CoCl2 Image

HSP Repairs Misfolded Proteins and Removes Debris

Unfolded Protein
HSP Repairs
Not Repairable Protein
Refolded Normal Protein
ETAS Flow1 Image

Supports Neuron Cell Growth

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ETAS Flow3 Image
Better Neural
Network Formation
ETAS Calculation Image
Placebo ETAS Bar Graph
# of correct answers

POMS (Profile of Mood States)

Placebo Graph
ETAS Graph

A New Study:
Ageing (senescence)-accelerated mice

  • Improved behavior and memory
  • HSP70 increased in brain
  • Amyloid-β decreased in brain
  • Neuron cells increased in brain
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A Standardized Extract of Asparagus officinalis Stem (ETAS®) Ameliorates Cognitive Impairment, Inhibits Amyloid β Deposition via BACE-1 and Normalizes Circadian Rhythm Signaling via MT1 and MT2

MDPI Nutrients Source
Depositions Bar Graph
Number of Neurons Bar Graph


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Heat, infection, inflammation, reactive oxygen species, UV, etc.

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HSP Expression Image
HSP expression increase
Function as

What is "Chaperone"?

Unfolded Ptotein Image

Unfolded protein
(dysfunctional / misfunctional)


HSP Chaperone Arrow Image
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Refolded Functional Protein Image

functional protein

Decomposed Protein Image

Decomposed protein
(if irreparable)

HSP expression and ETAS function mechanism

ETAS Stimulation

Flow Chart ETAS Stimulaiton
  1. HSP70 is stable as a complex with HSF1*1.
  2. When needed, HSP70 is released from the complex and activated.
    ⟶ to repair unfolded proteins.
  3. HSF-1 is phosphorylated and forms trimer.
  4. HSF-1 trimer moves into nucleus and binds to HSE*2 on DNA.
  5. Transcription and exportation of HSP70 mRNA
  6. HSP70 is translated to HSP70 protein.

  • *1 HSF-1: Heat shock factor-1
    Transcription factor which controls HP expression
  • *2 HSE: Heat shock element Gene sequences in promoter region

Reference: Cell Stress Chaperones. 2012 Jan:17/1):1-9.

The safety of ETAS is assured by in vitro, animal and clinical studies.
Regulatory Toxicology and pharmacology: submitted

Active Components

Several active components are identified in ETAS for Heat Shock Protein 70 (HSP70) induction, and ETAS is standardized with the component group “Asparaprolines” asparagus-derived proline-containing 3-alkyldiketopiperazines”.

Cyclo Atoms
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Asparaprolines; a standard component group of ETAS


ETAS is a natural ingredient derived from asparagus, which has been safely consumed as part of the food chain for at least 5,000 years. A 90-day toxicological study found no significant adverse events and confirmed the ingredient’s safety. [13]

For manufacturers seeking asparagus extract powder for sale, and those who are looking for asparagus extract powder bulk options, please contact your Maypro representative.